platelet-Rich plasma as a symptom- and disEaSe-modifying Treatment fOR knee ostEoarthritis (RESTORE)

Download Research Summary


The primary aim of this study was to investigate whether a series of three platelet-rich plasma (PRP) injections into the knee joint was effective in reducing pain and slowing loss of cartilage in the knee joint by comparing outcomes over 12 months. Safe and effective treatments that reduce symptoms of knee osteoarthritis and slow structural disease progression are needed. PRP, an autologous blood product that contains an elevated concentration of platelets, has biologic potential.

Status of project: completed

Download Research Summary


Prof Kim Bennell joins "Joint Action" to discuss results from the RESTORE study.

Listen to podcast


Effect of Intra-articular Platelet-Rich Plasma vs Placebo Injection on Pain and Medial Tibial Cartilage Volume in Patients With Knee Osteoarthritis: The RESTORE Randomized Clinical Trial

Go to article

Efficacy of intra-articular injections of platelet-rich plasma as a symptom- and disease-modifying treatment for knee osteoarthritis - the RESTORE trial protocol

Go to article

Statistical Analysis Plan

Infographic image of RESTORE Summary

Researchers involved in this study included Prof Kim Bennell, Prof Rana Hinman, Dr Kade Paterson, and Ben Metcalf at The University of Melbourne and The Royal North Shore Hospital, with collaborators from Monash University, Imaging @ Olympic Park and Castlereagh Imaging. The study was funded by the National Health and Medical Research Council.

See our other research summaries