platelet-Rich plasma as a symptom- and disEaSe-modifying Treatment fOR knee ostEoarthritis (RESTORE)

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The primary aim of this study was to investigate whether a series of three platelet-rich plasma (PRP) injections into the knee joint was effective in reducing pain and slowing loss of cartilage in the knee joint by comparing outcomes over 12 months. Safe and effective treatments that reduce symptoms of knee osteoarthritis and slow structural disease progression are needed. PRP, an autologous blood product that contains an elevated concentration of platelets, has biologic potential.

Status of project: completed

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Researchers involved in this study included Prof Kim Bennell, Prof Rana Hinman, Dr Kade Paterson, and Ben Metcalf at The University of Melbourne and The Royal North Shore Hospital, with collaborators from Monash University, Imaging @ Olympic Park and Castlereagh Imaging. The study was funded by the National Health and Medical Research Council.

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