Application of stem cell-derived neurons to the deaf cochlea
Successful replacement of damaged auditory neurons will have widespread health benefits by increasing the numbers of suitable candidates for cochlear implantation and by improving the benefits currently derived from this prosthesis. The goal of this program of research is to reverse the deafness-induced loss of auditory neurons, using stem cells as a source of replacement cells. A key step toward this goal is to determine whether these stem cell-derived neurons are capable of functional integration in the deaf auditory pathway, and whether their integration can be enhanced following electrical stimulation from a cochlear implant. Projects under this research theme involve multi-disciplinary, cross-institutional collaborations between A/Prof Mirella Dottori, A/Prof James Fallon and Prof Rob Shepherd.
- Ms Tomoko Hyakumura (post-doctoral research fellow)
- Ms Madeline Nciholson (research assistant)
- Ms Brianna Flynn (research assistant)
- Mr Basil Rasi (MBBS research student)
- Mr Matthew Wilson (Masters of Audioogy student)
- A/Prof Mirella Dottori, Centre for Neural Engineering
- A/Prof James Fallon, Bionics Institute
- Prof Rob Shepherd, Bionics Institute
Garnett Passe & Rodney Williams Memorial Foundation
This research project is available to PhD students to join as part of their thesis.
Please contact the Research Group Leader to discuss your options.
Nayagam, B.A.(CA), Backhouse, S.S, Cimenkaya, C. and Shepherd, R.K. (2012) Hydrogel limits stem cell dispersal in the deaf cochlea: implications for cochlear implants. Journal of Neural Engineering, Dec 9(6): 065001. doi: 10.1088/1741-2560/9/6/065001
Nayagam B.A.(CA) (2012) Human stem cells ameliorate auditory evoked responses in a model of neuropathy. Stem Cell Research and Therapy, 3:44-45
Backhouse, S.#, Coleman, B.# and Shepherd, R.K. (2008) Surgical access to the mammalian cochlea for cell-based therapies. Experimental Neurology, 214(2):193-200
Coleman, B.(CA), Hardman, J., Coco, A., Epp, S., de Silva, M., Crook, J., Shepherd, R.K. (2006) Fate of embryonic stem cells transplanted into the deafened mammalian cochlea. Journal of Cell Transplantation. 15:369-380.
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