DOVS publications appearing in PubMed over the September 2018 - January 2019 period.

Detecting glaucomatous progression with infrequent visual field testing.

Anderson AJ, Asokan R, Murata H, Asaoka R.

Ophthalmic Physiol Opt. 2018 Mar;38(2):174-182.

Testing visual field less frequently than recommended guidelines does not dramatically alter positive and negative predictive values for detecting rapid progression at 2 years, but does substantially delay when significant progression may first be detected.

Home Monitoring of Retinal Sensitivity on a Tablet Device in Intermediate Age-Related Macular Degeneration.

Adams M, Ho CYD, Baglin E, Sharangan P, Wu Z, Lawson DJ, Luu CD, Turpin A, McKendrick AM, Guymer RH.

Transl Vis Sci Technol. 2018 Oct 29;7(5):32.

It is feasible to use a home-based tablet device to monitor retinal sensitivity in intermediate age-related macular degeneration, with results comparable to clinic based measures.

Comparison of Rates of Fast and Catastrophic Visual Field Loss in Three Glaucoma Subtypes.

Anderson AJ, Chaurasia AK, Sharma A, Gupta A, Gupta S, Khanna A, Gupta V.

Invest Ophthalmol Vis Sci. 2019 Jan 2;60(1):161-167.

The proportion of Indian tertiary-care patients with rapid field loss was around half that reported in a Canadian dataset, despite median progression rates differing little. Examining full progression rate distributions is important, therefore.

Is experience in multi-genre video game playing accompanied by impulsivity?

Azizi E, Stainer MJ, Abel LA.

Acta Psychol (Amst). 2018 Oct;190:78-84.

Gaming was related to a more impulsive response style on attention and eye movement tests, but this wasn’t action game specific.

Contrast-dependent phase sensitivity in area MT of macaque visual cortex.

Cloherty SL, Ibbotson MR.

Neuroreport. 2019 Feb 6;30(3):195-201.

A general feature of cells in motion processing area MT is that they can be divided into pattern and component selective types. We found no correlation between this classification and contrast-dependent phase sensitivity.

Regional and functional heterogeneity of antigen presenting cells in the mouse brain and meninges.

Dando SJ, Kazanis R, Chinnery HR, McMenamin PG.

Glia. 2018 Dec 26. doi: 10.1002/glia.23581. [Epub ahead of print]

We compared the ability of resident immune cells from discrete brain and meningeal regions to present antigen to T cells. We found that dural dendritic cells were the most potent at activating naïve T cells.

Relating optical coherence tomography to visual fields in glaucoma: structure-function mapping, limitations and future applications.

Denniss J, Turpin A, McKendrick AM.

Clin Exp Optom. 2018 Nov 29.

This review article provides an update on relating structural parameters from OCT to visual fields test results in the context of glaucoma.

Appraising the Quality of Systematic Reviews for Age-Related Macular Degeneration Interventions: A Systematic Review.

Downie LE, Makrai E, Bonggotgetsakul Y, Dirito LJ, Kristo K, Pham MN, You M, Verspoor K, Pianta MJ.

JAMA Ophthalmol. 2018 Sep 1;136(9):1051-1061.

The methodological quality of systematic reviews in the field of age-related macular degeneration varies considerably. Clinicians need to be aware of this heterogeneity in methodological rigour when using this evidence to inform patient care.

Tear film inflammatory cytokine upregulation in contact lens discomfort.

Gad A, Vingrys AJ, Wong CY, Jackson DC, Downie LE.

Ocul Surf. 2019 Jan;17(1):89-97.

Contact lens discomfort is associated with higher tear film levels of the pro-inflammatory cytokine IL-17A, supporting an association between the discomfort response and low-grade, ocular surface inflammation.

A Model of Glaucoma Induced by Circumlimbal Suture in Rats and Mice.

He Z, Zhao D, van Koeverden AK, Nguyen CT, Lim JKH, Wong VHY, Vingrys AJ, Bui BV.

J Vis Exp. 2018 Oct 5;(140).

This visual demonstration provides a range of tips for successfully implementing the circumlimbal suture model of chronic intraocular pressure elevation. It also provides a summary of expected outcomes in two common laboratory species.

Anterior segment optical coherence tomography: its application in clinical practice and experimental models of disease.

Jiao H, Hill LJ, Downie LE, Chinnery HR.

Clin Exp Optom. 2018 Oct 1.

We reviewed recent studies involving spectral domain optical coherence tomography to investigate the anterior segment of the eye in both clinical and experimental settings.

An Electrophysiological Comparison of Contrast Response Functions in Younger and Older Adults, and Those With Glaucoma.

Lek JJ, Nguyen BN, McKendrick AM, Vingrys AJ.

Invest Ophthalmol Vis Sci. 2019 Jan 2;60(1):442-450.

Our study demonstrates that retinal and cortical responses to increasing contrast differ between healthy older adults and glaucoma patients, suggesting that glaucomatous effects are not a simple extension of ageing.

A Comparison between the Compass Fundus Perimeter and the Humphrey Field Analyzer.

Montesano G, Bryan SR, Crabb DP, Fogagnolo P, Oddone F, McKendrick AM, Turpin A, Lanzetta P, Perdicchi A, Johnson CA, Garway-Heath DF, Brusini P, Rossetti LM.

Ophthalmology. 2019 Feb;126(2):242-251.

The Compass perimeter is a new commercially available device that performs fixation stabilised perimetry (based on retinal IR image). This is the first study to compare to the HFA.

Midbrain dysfunction in anorexia nervosa.

Phillipou A, Abel LA, Castle DJ, Gurvich C, Hughes ME, Rossell SL.

Psychiatry Res Neuroimaging. 2018 Nov 6. pii: S0925-4927(18)30198-7.

A letter to the editor highlighting how recent findings have suggested dysfunction of midbrain regions in individuals with anorexia nervosa.

White matter microstructure in anorexia nervosa.

Phillipou A, Carruthers SP, Di Biase MA, Zalesky A, Abel LA, Castle DJ, Gurvich C, Rossell SL.

Hum Brain Mapp. 2018 Nov;39(11):4385-4392.

Extensive changes in white matter were observed on functional anisotropy and mean diffusivity in individuals with anorexia compared to matched controls. This may contribute to some of the pathophysiology.

An Overlooked Brain Region in the Aetiology of Anorexia Nervosa: The Importance of Behaviourally Driven Neuroimaging Analysis.

Phillipou A, Castle DJ, Abel LA, Gurvich C, Rossell SL.

J Exp Neurosci. 2018 Dec 20;12:1179069518820068.

Square wave jerks were an unexpected finding in anorexia patients. Hypotheses about possible loci of pathology led to the observation of white matter differences in the area of the superior colliculus.

Application of Pattern Recognition Analysis to Optimize Hemifield Asymmetry Patterns for Early Detection of Glaucoma.

Phu J, Khuu SK, Bui BV, Kalloniatis M.

Transl Vis Sci Technol. 2018 Sep 4;7(5):3.

Contrast sensitivity contours across the visual field grouped with pattern recognition provides a means for guiding test point selection for asymmetry analysis in glaucoma assessment.

Crowdsourcing critical appraisal of research evidence (CrowdCARE) was found to be a valid approach to assessing clinical research quality.

Pianta MJ, Makrai E, Verspoor KM, Cohn TA, Downie LE.

J Clin Epidemiol. 2018 Dec;104:8-14.

Crowdsourcing critical appraisal via CrowdCARE ( is a valid approach to assessing clinical research quality and has the potential to transform evidence-based practice by distributing the appraisal load across a global group of clinicians.

Irregularly timed electrical pulses reduce adaptation of retinal ganglion cells.

Soto-Breceda A, Kameneva T, Meffin H, Maturana M, Ibbotson MR.

J Neural Eng. 2018 Oct;15(5):056017.

We find that that retinal stimulation with random timed electrical pulses result in lower adaptation rates than stimulation with regularly timed pulses, which might reduce perceptual fading in retinal prostheses for bionic vision.

Improving Spatial Resolution and Test Times of Visual Field Testing Using ARREST.

Turpin A, Morgan WH, McKendrick AM.

Transl Vis Sci Technol. 2018 Oct 31;7(5):35.

A new approach to visual field testing that doesn’t waste time testing locations that are already known to be blind or be highly variable. Instead, additional test points are added to spatially describe the scotoma.

Optical coherence tomography angiography findings in a case of adult-onset vitelliform dystrophy.

Wang J, Tan J, Snibson K, Cham KM.

Clin Exp Optom. 2018 Oct 1.

OCT-A may reveal retinal blood flow disruption in adult-onset vitelliform dystrophy. As visualisation of the choriocapillaris is more difficult compared to inner retinal layers, artefacts should be considered.

Visual Snow: Visual Misperception.

White OB, Clough M, McKendrick AM, Fielding J.

J Neuroophthalmol. 2018 Dec;38(4):514-521.

This review article describes current understanding of the often misunderstood neurological disorder known as “visual snow”.