The immune system is key to fighting infection, but also plays a role in unwanted responses such as allergies and excessive chronic inflammation following clearance of pathogens.
Our research is aimed at assessing the biochemical mechanisms that underpin immunological and inflammatory responses in the eye (eg. corneal and retinal) and on the eye's surface (e.g. in conditions of dry eye and contact lens wear). The research is directed to understand the cellular and chemical mechanisms of eye disease, with the translational goal of improved treatments for eye disorders. Additionally, inflammation plays a key role in normal wound healing whereas abnormal inflammatory responses are associated with the most common forms of chronic lower limb ulceration. Our research explores methods of identifying and managing chronic inflammatory changes in leg ulcers and other chronic wounds.