Departmental and staff publications.
Detecting glaucomatous progression with infrequent visual field testing.
Anderson AJ, Asokan R, Murata H, Asaoka R. Ophthalmic Physiol Opt. 2018 Mar;38(2):174-182.
Testing visual field less frequently than recommended guidelines does not dramatically alter positive and negative predictive values for detecting rapid progression at 2 years, but does substantially delay when significant progression may first be detected.
Sampling the Visual Field Based on Individual Retinal Nerve Fiber Layer Thickness Profile.
Ballae Ganeshrao S, Turpin A, McKendrick AM.
Invest Ophthalmol Vis Sci. 2018 Feb 1;59(2):1066-1074.
Current perimeters use fixed grid patterns. We find that using structural information (nerve fibre layer thickness) to choose locations to test in a VF for individual patients identifies more abnormal locations than using existing fixed grid patterns.
Understanding glaucoma pathogenesis.
Clin Exp Ophthalmol. 2017 Dec;45(9):853.
A commentary on the importance of considering the appropriateness of animal models in research.
Attentional asymmetry between visual hemifields is related to habitual direction of reading and its implications for debate on cause and effects of dyslexia.
Kermani M, Verghese A, Vidyasagar TR.
Dyslexia. 2018 Feb;24(1):33-43. doi: 10.1002/dys.1574.
Controversy surrounds whether any of the many visual and phonological deficits found to be correlated with reading difficulty cause the impairment or result from the reduced amount of reading done by dyslexics. By studying people who read left-to-right or right-to-left, we show reading experience biases search performance in the direction of reading.
Electrical receptive fields of retinal ganglion cells: Influence of presynaptic neurons.
Maturana MI, Apollo NV, Garrett DJ, Kameneva T, Cloherty SL, Grayden DB, Burkitt AN, Ibbotson MR, Meffin H.
PLoS Comput Biol. 2018 Feb 12;14(2):e1005997. doi: 10.1371/journal.pcbi.1005997.
We present a computational model that accurately predicts both the spatial and temporal nonlinear interactions of multi-electrode stimulation of rat retinal ganglion cells (RGCs), and show that the nonlinearities arise largely from activation of presynaptic interneurons.
Mismatched summation mechanisms in older adults for the perception of small moving stimuli.
McDougall TJ, Nguyen BN, McKendrick AM, Badcock DR. Vision Res. 2018 Jan;142:52-57.
Previous studies have found evidence for reduced cortical inhibition in aging visual cortex. The present study on motion direction suggests aging impacts on short-range summation mechanisms.
Congenital achiasma and see-saw nystagmus in VATER syndrome association with hydrocephalus.
Nguyen CT, Goh C, Desmond P, Abel LA, Lim CHL, Andrew Symons RC, Hardy TG. J Clin Neurosci. 2018 Feb 23. pii: S0967-5868(17)31240-7.
We report a case of congenital achiasma and see-saw nystagmus with VATER association and hydrocephalus. fMRI showed isolated activation of the ipsilateral visual cortex upon stimulation. Despite the lack of nasal retinal fiber decussation, the visual field was intact.
Acute caffeine ingestion affects surround suppression of perceived contrast.
Nguyen BN, Hew SA, Ly J, Shin HY, Wong JC, Yeung E, McKendrick AM. J Psychopharmacol. 2018 Jan;32(1):81-88.
We find that acute consumption of caffeine influences perceptual surround suppression strength. Perceptual surround suppression is predominantly attributed to inhibitory processes involving the major cortical inhibitory neurotransmitter, gamma-aminobutyric acid.
Differences in regional grey matter volumes in currently ill patients with anorexia nervosa.
Phillipou A, Rossell SL, Gurvich C, Castle DJ, Abel LA, Nibbs RG, Hughes ME. Eur J Neurosci. 2018 Jan;47(2):177-183.
Neurobiological findings in anorexia nervosa are inconsistent, including differences in regional grey matter volumes. Methodological limitations often contribute to these inconsistencies. Using an improved analysis method, we find reduced grey matter volumes in anorexia nervosa that are associated with eating disorder symptomatology.
How Many Subjects are Needed for a Visual Field Normative Database? A Comparison of Ground Truth and Bootstrapped Statistics.
Phu J, Bui BV, Kalloniatis M, Khuu SK. Transl Vis Sci Technol. 2018 Mar 2;7(2):1.
We provide guidance for choosing the cohort size for different levels of error when performing normative comparisons with glaucoma patients.
Six-month longitudinal comparison of a portable tablet perimeter with the Humphrey Field Analyser.
Prea SM, Kong YXG, Mehta A, He M, Crowston JG, Gupta V, Martin KR, Vingrys AJ. Am J Ophthalmol. 2018 Mar 14. pii: S0002-9394(18)30107-7.
The Melbourne Rapid Fields (MRF) is an iPad-based perimeter. The MRF correlated strongly with conventional perimetry across 4 visits over a 6-month period, with good reliability. The MRF is suitable for monitoring visual fields in settings where conventional perimetry is not readily accessible.
Saccades under Mental Load in Infantile Nystagmus Syndrome and Controls.
Salehi Fadardi M, Abel LA.
Optom Vis Sci. 2018 Apr;95(4):373-383.
We examined saccades and visual task performance in patients with infantile nystagmus syndrome (INS) under mental load. Our results highlighted that to more completely evaluate INS therapies recognition time should also be measured with mental load, resembling real-world conditions.
The interpretation of results of 10-2 visual fields should consider individual variability in the position of the optic disc and temporal raphe.
Tanabe F, Matsumoto C, McKendrick AM, Okuyama S, Hashimoto S, Shimomura Y. Br J Ophthalmol. 2018 Mar;102(3):323-328.
The anatomical position of the optic disc and the temporal raphe affects the mapping between structure and function with respect to superior and inferior hemifields.
Fostering Spontaneous Visual Attention in Children on the Autism Spectrum: A Proof-of-Concept Study Comparing Singing and Speech.
Thompson GA, Abel LA. Autism Res. 2018 Jan 22
In this study, children with autism spectrum watched videos of someone singing or reading a story. The results show that children look more at the person if they were singing and if the story was familiar to them.
AAV-mediated gene delivery of the calreticulin anti-angiogenic domain inhibits ocular neovascularization.
Tu L, Wang JH, Barathi VA, Prea SM, He Z, Lee JH, Bender J, King AE, Logan GJ, Alexander IE, Bee YS, Tai MH, Dusting GJ, Bui BV, Zhong J, Liu GS.
Angiogenesis. 2018 Feb;21(1):95-109.
Using in vitro and in vivo models we show that calreticulin delivery to the eye using an adeno associate virus show promise as a treatment for abnormal growth of blood vessels.
Omega-3 polyunsaturated fatty acid supplementation for improving peripheral nerve health: protocol for a systematic review.
Zhang AC, MacIsaac RJ, Roberts L, Kamel J, Craig JP, Busija L, Downie LE. BMJ Open. 2018 Mar 25;8(3):e020804.
The aim of this systematic review is to assess the effects of oral omega-3 PUFA supplementation on peripheral nerve integrity, including both subjective and objective measures of peripheral nerve structure and/or function.
Age-related changes in the response of retinal structure, function and blood flow to pressure modification in rats.
Zhao D, Nguyen CTO, He Z, Wong VHY, van Koeverden AK, Vingrys AJ, Bui BV. Sci Rep. 2018 Feb 13;8(1):2947.
Peripapillary optic nerve tissue are less flexible in older eyes. This might account for why ganglion cell function in older eyes is more susceptible to acute intraocular pressure elevation.