Using our novel model of glaucoma to understand if ganglion cells can recover from injury

Project Details

We have developed a novel laboratory model of chronic eye pressure elevation. This model shares many characteristics seen in human glaucoma; selective and progressive ganglion cell dysfunction. This will allow us to study the mechanisms underlying ganglion cell injury caused by chronic eye pressure elevation. The model may be particularly useful as the eye pressure can be quickly reversed. This opens up the possibility of study the mechanisms that facilitate the recovery of ganglion cell structure and function.

Chronic IOP elevation

Figure: Chronic IOP elevation achieved via a circumlimbal suture (A & B) produces IOP elevation (C). Greater loss of ganglion cell function is observed compared with outer retinal responses (D). OCT reveals RNFL thinning (E vs F, & H), whereas overall retinal thickness was unchanged (G). Retinal histology shows a reduction in the number of cells found in the inner retina (I).

Research Group

Ocular Physiology Laboratory



Faculty Research Themes

Neuroscience

School Research Themes

Sensory Neuroscience, Immunology and Inflammation, Practice and service improvement



Key Contact

For further information about this research, please contact the research group leader.

Department / Centre

Optometry and Vision Sciences

Unit / Centre

Ocular Physiology Laboratory