Evaluation of vascular, glial and functional deficits in diabetic eye disease
Diabetic eye disease affects at least 7 in 10 sufferers of Type 1 diabetes. In some individual it can lead to blindness. There is convincing data that early in the development of eye disease neurons, blood vessels and supporting glial cell are affected. This triad of cells blood vessels, neurons and glia participate in what is known as "neurovascular coupling". If the glial cells cant tell blood vessels to increase flow or if the blood vessels cant react to the change in demand then the neurons will suffer. We will study changes to neurovascular coupling using laboratory models of Type I diabetes.
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