In vivo physiological characterisation of Parkinson’s disease
The retina’s electrophysiological response to flashes of light have been shown to be highly discriminating of those with Parkinson’s disease from controls. These changes are thought to be driven by dopamine, the most abundant catecholamine in the retina. Importantly, such anomalies are ameliorated by L-DOPA therapy. Dopamine has multiple roles in the retina including modification of light adaptation and alteration to ON-OFF responses in bipolar cells. Thus by utilising electroretinography techniques which target these dynamic responses may potentially provide a more sensitive marker of dopamine abnormalities in the preclinical and clinical setting. This project aims to evaluate whether this is the case in a transgenic mouse model of Parkison’s disease over a range of ages.