Publications

Do Intense Perimetric Stimuli Saturate the Healthy Visual System?

Anderson AJ, McKendrick AM, Turpin A.

Invest Ophthalmol Vis Sci. 2016 Nov 1;57(14):6397-6404.

A recent proposal is that glaucomatous perimetric sensitivities are variable because intense perimetric targets saturate retinal ganglion cell responses. We find good contrast discrimination between intense targets, suggesting significant saturation does not occur.

Significant Glaucomatous Visual Field Progression in the First Two Years: What Does It Mean?

Anderson AJ.

Transl Vis Sci Technol. 2016 Nov 1;5(6):1.

Statistically significant visual field progression in a short period after diagnosis may not necessarilyindicate the presence of rapid progression, and so confirmatory signs of rapid progression should be sought before implementing treatment changes.

Automatic identification of the temporal retinal nerve fiber raphe from macular cube data.

Bedggood P, Tanabe F, McKendrick AM, Turpin A.

Biomed Opt Express. 2016 Sep 15;7(10):4043-4053.

We evaluated several approaches for automatic location of the temporal nerve fiber raphe from standard OCT macular cubes. The best approach involved projection of a fan of lines from each of several locations across the foveal pit.

Stretch Sensitive Channels in Retinal Blood Flow Autoregulation.

Bui BV.

Invest Ophthalmol Vis Sci. 2016 Oct 1;57(13):5648.

A short editorial highlighting some excellent work in the journal describing novel findings from McGahon et al (2016) showing that TRPV2 channels contribute to constriction in retinal arterioles.

A Randomized, Double-Masked, Placebo-Controlled Clinical Trial of Two Forms of Omega-3 Supplements for Treating Dry Eye Disease.

Deinema LA, Vingrys AJ, Wong CY, Jackson DC, Chinnery HR, Downie LE.

Ophthalmology. 2016 Nov 3. pii: S0161-6420(16)31373-2.

Moderate doses of long-chain omega-3 supplements, for three months, reduce tear osmolarity and increase tear stability in dry eye. Krill oil may confer additional therapeutic benefit compared with fish oil, through differentially modulating ocular inflammation.

Impact of Peripheral Field Loss on the Execution of Natural Actions: A Study With Glaucomatous Patients and Normally Sighted People.

Dive S, Rouland JF, Lenoble Q, Szaffarczyk S, McKendrick AM, Boucart M.

J Glaucoma. 2016 Oct;25(10):e889-e896.

Although slower than controls, patients with glaucoma can accomplish natural actions efficiently even when the task requires discrimination of small structurally similar objects (nuts and screws in a model-building task).

Visual Neuroscience: Unique Neural System for Flight Stabilization in Hummingbirds.

Ibbotson MR.

Curr Biol. 2017 Jan 23;27(2):R58-R61.

The pretectal visual motion area in the hummingbird brain codes for motion in all directions through 360°, instead of emphasizing horizontal motion as in other birds, possibly offering precise visual stability control during hovering.

A Comparison of Perimetric Results from a Tablet Perimeter and Humphrey Field Analyzer in Glaucoma Patients.

Kong YX, He M, Crowston JG, Vingrys AJ.

Transl Vis Sci Technol. 2016 Nov 3;5(6):2.

We find that portable tablet perimetry (MRF) allows fast and accurate assessment of visual fields in 90 patients especially when HFA or Medmont is unavailable or unsuitable.

Glial Cell Contribution to Basal Vessel Diameter and Pressure-Initiated Vascular Responses in Rat Retina.

Li H, Bui BV, Cull G, Wang F, Wang L.

Invest Ophthalmol Vis Sci. 2017 Jan 1;58(1):1-8.

Changes in blood or eye pressure initiates compensatory reaction from blood vessels throughout the body. In the eye this compensatory response is altered when the support cells, or glial cells surrounding blood vessel is removed.

The Eye As a Biomarker for Alzheimer’s Disease.

Lim JK, Li QX, He Z, Vingrys AJ, Wong VH, Currier N, Mullen J, Bui BV, Nguyen CT.

Front Neurosci. 2016 Nov 17;10:536. Review.

A review of the ocular changes associated with Alzheimers disease,
with commentary on how these might be used to develop vision tests and
ocular imaging methods as “biomarkers” for early detection and monitoring
of Alzheimer’s.

Reversal of functional loss in a rat model of chronic intraocular  pressure elevation.

Liu HH, He Z, Nguyen CT, Vingrys AJ, Bui BV.

Ophthalmic Physiol Opt. 2016 Oct 24.

A simple circumlimbal suture can be used to raise rodent IOP. We show that after suture removal and consequent IOP lowering, ganglion cells retain the capacity to recover despite an extended period of intraocular pressure elevation.

Intraocular Pressure Induced Retinal Changes Identified Using Synchrotron Infrared Microscopy.

Shen HH, Liu GS, Chow SH, Wang JH, He Z, Nguyen C, Lin TW, Bui BV.

PLoS One. 2016 Oct 6;11(10):e0164035.

We demonstrate that synchrotron infrared imaging (SIRM) can quantify the effect of IOP elevation on specific retinal layers, suggesting it may be a useful tool for laboratory studies of localised tissue changes in glaucoma and other
eye diseases.

Temporal changes in contact lens comfort over a day of wear.

Woods CA, Bentley SA, Fonn D.

Ophthalmic Physiol Opt. 2016 Nov;36(6):643-648.

Symptomatic contact lens wearers report progressive decrease in comfort, independent of material; asymptomatic wearers do not. Exclusion of asymptomatic wearers may increase sensitivity of comfort ratings in contact
lens research.

A Possible Role for End-Stopped V1 Neurons in the Perception of Motion:  A Computational Model.

Zarei Eskikand P, Kameneva T, Ibbotson MR, Burkitt AN, Grayden DB.

PLoS One. 2016 Oct 14;11(10):e0164813.

We present a model of the early stages of processing in the visual cortex, in particular V1 and MT, to investigate the potential role of end-stopped V1
neurons in solving the aperture problem.